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Symbol Name ID |
Ptpn11
protein tyrosine phosphatase, non-receptor type 11 MGI:99511 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Juvenile myelomonocytic leukemia |
Abnormality of the lymphatic system |
Abnormality of the spleen |
| Disease(s) Associated with PTPN11 | |||
| juvenile myelomonocytic leukemia | |||
| Noonan syndrome | |||
| Noonan syndrome 1 |
| Mouse Phenotypes | immune system phenotype |
enlarged spleen |
increased spleen weight |
abnormal leukopoiesis |
arrested B cell differentiation |
myeloid hyperplasia |
increased neutrophil cell number |
increased granulocyte number |
increased lymphocyte cell number |
increased monocyte cell number |
increased leukocyte cell number |
intermingled spleen red and white pulp |
abnormal splenic cell ratio |
increased circulating interleukin-6 level |
increased acute inflammation |
liver inflammation |
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| Availability | Mouse Genotype | ||||||||||||||||
| Ptpn11tm1.1Ics/Ptpn11+ | |||||||||||||||||
| Ptpn11tm1Bgn/Ptpn11+ | |||||||||||||||||
| Ptpn11tm1Gsf/Ptpn11tm1Gsf Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ptpn11tm1Ckq/Ptpn11+ Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Ptpn11tm1Ckq/Ptpn11+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Ptpn11tm1Ckq/Ptpn11+ Tg(Lck-cre)1Cwi/0 (conditional) |
* | ||||||||||||||||
| Ptpn11tm6Bgn/Ptpn11+ Tg(CAG-cre/Esr1*)5Amc/0 (conditional) |
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| Ptpn11tm6Bgn/Ptpn11+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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